Case at a Glance

Design
Single-patient clinical case. Not a controlled trial.
Site
Posterior neck skin, same region at baseline and follow-up
Duration
90 days
Nutrition
Mendora Skin Repair Formula, daily throughout
Procedures
One superficial chemical peel and two microneedling sessions
Assessment
Independent, blinded dermatopathology review

This is a single clinical case using a combined protocol. It does not prove that Mendora alone caused the changes seen in the tissue.

The Protocol · What We Did

01 / Day 0

Baseline

A punch biopsy of the posterior neck documented the starting architecture. The patient began taking the Skin Repair Formula daily and had a clinician-administered superficial chemical peel.

02 / ~Day 30

Microneedling

First microneedling session over the same area of skin.

03 / ~Day 60

Microneedling

Second microneedling session over the same area of skin.

04 / Day 90

Follow-up

A second biopsy of the same region was taken and compared against baseline.

The Mendora Skin Repair Formula was taken daily across the full 90 days.

The Evidence · What the Tissue Showed

Fig 1 · Dermal elastin Elastin stain · same magnification
BaselineH and E stain at baseline
Baseline, 2025. Elastin in the mid dermis is sparse and shows prominent fragmentation, the pattern of elastolysis. The fibers appear short and broken.
90 DaysH and E stain at 90 days
90 days, 2026. Elastin density in the mid dermis is markedly higher, with a 2 to 3 fold increase in the number of fibers and roughly a 2 fold increase in bundle size. The fibers are long, wavy, and darkly stained, with no fragmentation.

Arrows are illustrative. Read by an independent, board-certified dermatopathologist, blinded to the treatment, comparing the baseline and 90 day samples

Fig 2 · Epidermis & collagen H&E · same magnification
BaselineH and E stain at baseline
Baseline, 2025. The epidermis averages about 0.08 mm. Dermal collagen is finer and less densely packed, on the order of 6 to 7 thin fibers per 0.1 mm.
90 Days
90 days, 2026. The epidermis is slightly thicker, averaging about 0.10 mm. Collagen is thicker and more densely packed, averaging 4 to 5 thick fibers per 0.1 mm. Sparse perivascular inflammation is also present, consistent with tissue that is still actively remodeling.

Arrows are illustrative; epidermal measurements are the reader's. From the same blinded read of the baseline and 90 day samples.

The Read · Independent & Blinded

ParameterBaseline to 90 days
Dermal elastin sparse, fragmented to 2 to 3× more fibers; longer, continuous, no fragmentation
Dermal collagen 6 to 7 thin fibers / 0.1 mm to 4 to 5 thicker, densely packed fibers / 0.1 mm
Epidermal thickness ~0.08 mm to ~0.10 mm
Read by an independent, board-certified dermatopathologist, blinded to the treatment.
What this means

What Changed
Under the Microscope.

Skin owes its bounce and firmness to two proteins in the dermis, the layer beneath the surface. Elastin is what lets skin spring back after it stretches, and with age it breaks apart, which is the fragmentation the pathologist described at baseline. Collagen is the scaffold that keeps skin firm and thick. In this case, the 90 day tissue showed elastin that was denser and continuous rather than broken, collagen that was thicker and more tightly packed, and a slightly thicker outer layer. In plain terms, the follow-up skin looked better organized under the microscope than it did at the start.

It helps to be clear about what did the work. The superficial peel and the two microneedling sessions are established procedures that prompt the skin to remodel its own collagen and elastin, and they account for much of the visible change. The Skin Repair Formula was taken daily throughout to support that repair from within. The result reflects the combination, not any single step.

One case, more to come

These images come from a single person, and the procedures drove much of what changed, so this is not a controlled comparison of any one product and individual results vary. A controlled series, one that separates the nutrition from the procedures and reads many samples, is what would turn an interesting result like this into evidence. That work is underway.

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Mendora · Skin Repair Formula

Histology images de-identified and used with patient authorization. This content is educational and is not medical advice. The Mendora Skin Repair Formula is a dietary supplement and is not intended to diagnose, treat, cure, or prevent any disease.

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